5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

Base Information

Chemical Name:5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one
CAS No.:315682-14-5
Molecular Formula:C₂₀H₁₄Cl₂F₆O₃
Molecular Weight:487.226
Hs Code.:

Synonyms:5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

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Technology Process of 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

There total 7 articles about 5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 199997-50-7
4-(3,4-dichloro-phenyl)-5-hydroxymethyl-dihydro-furan-2-one

: 315682-14-5
5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

Guidance literature:: With silver(l) oxide; In N,N-dimethyl-formamide; at 23 ℃; for 48h;
DOI:10.1016/S0960-894X(00)00463-7

Reference yield:

: 7312-27-8
3,4-Dichlorocinnamic acid

: 315682-14-5
5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: Cs₂CO₃

2: DIBAL-H

3: pyridine; DMAP

4: KHMDS; TESCl / tetrahydrofuran / 3 h / Heating

5: m-CPBA

6: Amberlyst 15

7: 71 percent / Ag₂O / dimethylformamide / 48 h / 23 °C

With pyridine; dmap; Amberlyst 15; triethylsilyl chloride; potassium hexamethylsilazane; diisobutylaluminium hydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Methylation / 2: Reduction / 3: Acetylation / 4: Ireland-Claisen rearrangement / 5: Epoxidation / 6: lactonization / 7: Alkylation;
DOI:10.1016/S0960-894X(00)00463-7

Reference yield:

: 148775-22-8
3-(3,4-dichlorophenyl)-prop-2-en-1-ol

: 315682-14-5
5-(3,5-bis-trifluoromethyl-benzyloxymethyl)-4-(3,4-dichloro-phenyl)-dihydro-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine; DMAP

2: KHMDS; TESCl / tetrahydrofuran / 3 h / Heating

3: m-CPBA

4: Amberlyst 15

5: 71 percent / Ag₂O / dimethylformamide / 48 h / 23 °C

With pyridine; dmap; Amberlyst 15; triethylsilyl chloride; potassium hexamethylsilazane; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Acetylation / 2: Ireland-Claisen rearrangement / 3: Epoxidation / 4: lactonization / 5: Alkylation;
DOI:10.1016/S0960-894X(00)00463-7