1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Base Information

Chemical Name:1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone
CAS No.:184968-72-7
Molecular Formula:C₃₁H₂₉Cl₂F₆NO₃
Molecular Weight:648.473
Hs Code.:

Synonyms:1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Suppliers and Price of 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

There total 12 articles about 1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 226917-14-2
[[((3,5-bis(trifluoromethyl)phenyl)methoxy)-methyl]-2-(3,4-dichlorophenyl)]-4-hydroxy-4-phenyl-1-piperidinebutanol

: 184968-72-7
1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: With Jones reagent; In acetone; at 0 ℃; for 1h;

Reference yield:

: 40807-61-2
4-hydroxy-4-phenylpiperidin

: 184968-72-7
1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₃CN; 3 A mol. siev. / 2,2,2-trifluoro-ethanol

With 3 A mol. siev; sodium cyanoborohydride; In 2,2,2-trifluoroethanol; 1: reductive amination / 2: Jones oxidation;
DOI:10.1016/S0960-894X(00)00463-7

Reference yield:

: 7312-27-8
3,4-Dichlorocinnamic acid

: 184968-72-7
1?[(3.5-bis(trifluoromethyl)phenyl)methoxy]-3-(3,4-dichlorophenyl)-5-(4-hydroxy-4-phenyl-1-piperidinyl)-2-pentanone

Guidance literature:: Multi-step reaction with 10 steps

1: Cs₂CO₃

2: DIBAL-H

3: pyridine; DMAP

4: KHMDS; TESCl / tetrahydrofuran / 3 h / Heating

5: m-CPBA

6: Amberlyst 15

7: 71 percent / Ag₂O / dimethylformamide / 48 h / 23 °C

8: DIBAL-H

9: NaBH₃CN; 3 A mol. siev. / 2,2,2-trifluoro-ethanol

With pyridine; dmap; Amberlyst 15; triethylsilyl chloride; 3 A mol. siev; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium cyanoborohydride; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In tetrahydrofuran; 2,2,2-trifluoroethanol; N,N-dimethyl-formamide; 1: Methylation / 2: Reduction / 3: Acetylation / 4: Ireland-Claisen rearrangement / 5: Epoxidation / 6: lactonization / 7: Alkylation / 8: Reduction / 9: reductive amination / 10: Jones oxidation;
DOI:10.1016/S0960-894X(00)00463-7