1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine

Base Information

• Chemical Name: 1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine
• CAS No.: 1314696-40-6
• Molecular Formula: C₂₃H₃₀FN₃O₃S
• Molecular Weight: 446.576

Synonyms:1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine

Chemical Property of 1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine

Chemical Property:

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Technology Process of 1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine

There total 6 articles about 1-(2-((2R)-1-[(4-[⁽¹⁹⁾F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine (1314696-33-7) → 1-(2-((2R)-1-[(4-[(19)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine (1314696-40-6)

Guidance literature:

With [¹⁸F]-potassium fluoride; [2.2.2]cryptande; In dimethyl sulfoxide; at 150 ℃; for 0.166667h;

DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl)pyrrolidine-1-carboxylate (1314696-17-7) → 1-(2-((2R)-1-[(4-[(19)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine (1314696-40-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 50 °C

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4: [¹⁸F]-potassium fluoride; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 150 °C

With lithium aluminium tetrahydride; [¹⁸F]-potassium fluoride; triethylamine; [2.2.2]cryptande; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl)pyrrolidine-1-carboxylate (1314696-19-9) → 1-(2-((2R)-1-[(4-[(19)F]-fluorophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)-4-(2-methoxyphenyl)piperazine (1314696-40-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 50 °C

2: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

3: [¹⁸F]-potassium fluoride; [2.2.2]cryptande / dimethyl sulfoxide / 0.17 h / 150 °C

With [¹⁸F]-potassium fluoride; triethylamine; [2.2.2]cryptande; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2011.05.010

upstream raw materials:

tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl)pyrrolidine-1-carboxylate

tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl)pyrrolidine-1-carboxylate

1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

4-Nitrobenzenesulfonyl chloride

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