1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

Base Information

Chemical Name:1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine
CAS No.:1314696-33-7
Molecular Formula:C₂₃H₃₀N₄O₅S
Molecular Weight:474.581
Hs Code.:

Synonyms:1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

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Chemical Property of 1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

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Technology Process of 1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

There total 5 articles about 1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₇N₃O

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1314696-33-7
1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

: 1314696-19-9
tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl)pyrrolidine-1-carboxylate

: 1314696-33-7
1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 50 °C

2: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2011.05.010

Reference yield:

: 1314696-17-7
tert-butyl (2R)-2-(2-[4-(2-methoxyphenyl)piperazin-1-yl]-2-oxoethyl)pyrrolidine-1-carboxylate

: 1314696-33-7
1-(2-methoxyphenyl)-4-(2-((2R)-1-[(4-nitrophenyl)sulfonyl]pyrrolidin-2-yl)ethyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 0 - 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 50 °C

3: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.010