C₁₄H₁₁F₃N₂O₃

Base Information

Chemical Name:C₁₄H₁₁F₃N₂O₃
CAS No.:1371609-31-2
Molecular Formula:C₁₄H₁₁F₃N₂O₃
Molecular Weight:312.248
Hs Code.:

C<sub>14</sub>H<sub>11</sub>F<sub>3</sub>N<sub>2</sub>O<sub>3</sub>

Synonyms:C₁₄H₁₁F₃N₂O₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₄H₁₁F₃N₂O₃

Chemical Property:

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Technology Process of C₁₄H₁₁F₃N₂O₃

There total 6 articles about C₁₄H₁₁F₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1371609-30-1
4-((4S,5S)-4-(hydroxymethyl)-5-methyl-2-oxooxazolidin-3-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

: 1371609-31-2
C₁₄H₁₁F₃N₂O₃

Guidance literature:: With Dess-Martin periodane; In acetonitrile; at 0 ℃; for 4h; Inert atmosphere;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1371609-31-2
C₁₄H₁₁F₃N₂O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 16 h / 0 - 80 °C / Inert atmosphere

2.2: pH ~ 3

3.1: potassium hydroxide / diethyl ether

3.2: 0.5 h / 0 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

5.1: ethanol; sodium tetrahydroborate / 4 h / 0 - 20 °C / Inert atmosphere

6.1: Dess-Martin periodane / acetonitrile / 4 h / 0 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; sodium tetrahydroborate; n-butyllithium; ethanol; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1182367-75-4
4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile

: 1371609-31-2
C₁₄H₁₁F₃N₂O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 0 - 80 °C / Inert atmosphere

1.2: pH ~ 3

2.1: potassium hydroxide / diethyl ether

2.2: 0.5 h / 0 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol; sodium tetrahydroborate / 4 h / 0 - 20 °C / Inert atmosphere

5.1: Dess-Martin periodane / acetonitrile / 4 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; ethanol; potassium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile;