(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

Base Information

Chemical Name:(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate
CAS No.:1371609-28-7
Molecular Formula:C₁₄H₁₅F₃N₂O₃
Molecular Weight:316.28
Hs Code.:

Synonyms:(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

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Chemical Property of (2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

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Technology Process of (2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

There total 3 articles about (2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 684-93-5
1-methyl-1-nitrosourea

: 1182368-12-2
(2R,3S)-2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoic acid

: 1371609-28-7
(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

Guidance literature:: 1-methyl-1-nitrosourea; With potassium hydroxide; In diethyl ether;

(2R,3S)-2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoic acid; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1371609-28-7
(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 5 h / -78 °C / Inert atmosphere

1.2: 16 h / -78 - 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 16 h / 0 - 80 °C / Inert atmosphere

2.2: pH ~ 3

3.1: potassium hydroxide / diethyl ether

3.2: 0.5 h / 0 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate; potassium hydroxide; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;

Reference yield:

: 1182367-75-4
4-fluoro-3-methyl-2-(trifluoromethyl)benzonitrile

: 1371609-28-7
(2R,3S)-methyl 2-((4-cyano-2-methyl-3-(trifluoromethyl)phenyl)amino)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 0 - 80 °C / Inert atmosphere

1.2: pH ~ 3

2.1: potassium hydroxide / diethyl ether

2.2: 0.5 h / 0 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In diethyl ether; dimethyl sulfoxide;