[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

Base Information

Chemical Name:[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid
CAS No.:1379928-82-1
Molecular Formula:C₂₈H₃₃FNO₃P
Molecular Weight:481.547
Hs Code.:

Synonyms:[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

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Chemical Property of [3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

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Technology Process of [3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

There total 5 articles about [3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13138-33-5
3-aminopropanephosphonic acid

: 1379649-46-3
4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

: 1379928-82-1
[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

Guidance literature:: 3-aminopropanephosphonic acid; 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde; In methanol; at 50 ℃; for 0.5h;

With sodium cyanoborohydride; In methanol; at 50 ℃; for 3h;

Reference yield:

: 78022-19-2
dimethyl (4-carbomethoxybenzyl)phosphonate

: 1379928-82-1
[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2.2: -20 °C / Celite

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

4.1: tert-butyl ammonium hydroxide / methanol / 0.5 h / 50 °C

4.2: 3 h / 50 °C

With tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1379649-44-1
{4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]phenyl}methanol

: 1379928-82-1
[3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propyl]phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

2.1: tert-butyl ammonium hydroxide / methanol / 0.5 h / 50 °C

2.2: 3 h / 50 °C

With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In methanol; dichloromethane; acetonitrile;