4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

Base Information

Chemical Name:4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde
CAS No.:1379649-46-3
Molecular Formula:C₂₅H₂₃FO
Molecular Weight:358.455
Hs Code.:

Synonyms:4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

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Chemical Property of 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

Chemical Property:

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Technology Process of 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

There total 8 articles about 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379649-44-1
{4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]phenyl}methanol

: 1379649-46-3
4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; acetonitrile; at 20 ℃; for 2h; Molecular sieve;

Reference yield:

: 1379649-41-8
3-(3,4-dimethylphenyl)-2-(3-fluorophenyl)propanal

: 1379649-46-3
4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2.2: -20 °C / Celite

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

With tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1379649-43-0
3-(3,4-dimethylphenyl)-2-(3-fluorophenyl)propanenitrile

: 1379649-46-3
4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / toluene / 3 h / -78 - -20 °C / Inert atmosphere

1.2: -20 °C / Celite

2.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

2.2: 2 h / 0 °C

3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 - 20 °C / Inert atmosphere

3.2: -20 °C / Celite

4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

With tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;