5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

Base Information

Chemical Name:5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile
CAS No.:1290137-97-1
Molecular Formula:C₁₆H₁₄N₄O₂
Molecular Weight:294.313
Hs Code.:

Synonyms:5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

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Chemical Property of 5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

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Technology Process of 5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

There total 6 articles about 5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1290138-30-5
5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

: 1290137-97-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: 5-(3,5-dimethylisoxazol-4-yl)-1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile; With boron tribromide; In dichloromethane; at 20 ℃;

With water; In dichloromethane;

Reference yield:

: 5417-82-3
(1-ethoxyethylidene)malononitrile

: 1290137-97-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 0.33 h / 105 °C / microwave irradiation

2: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 50 °C

3: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; 1,2-dimethoxyethane / 0.5 h / 145 °C / Inert atmosphere; microwave irradiation

4: boron tribromide / dichloromethane / 20 °C

With diiodomethane; boron tribromide; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 1290137-97-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; 1,2-dimethoxyethane / 0.5 h / 145 °C / Inert atmosphere; microwave irradiation

3.1: boron tribromide / dichloromethane / 20 °C

With n-butyllithium; boron tribromide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; hexane; dichloromethane;