5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

Base Information

Chemical Name:5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide
CAS No.:1290137-74-4
Molecular Formula:C₁₆H₁₇N₅O₃
Molecular Weight:327.343
Hs Code.:

Synonyms:5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

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Chemical Property of 5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

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Technology Process of 5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

There total 7 articles about 5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1290137-97-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carbonitrile

: 1290137-71-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxamide

: 1290137-74-4
5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

Guidance literature:: With hydroxylamine hydrochloride; water; sodium hydrogencarbonate; In methanol; at 130 ℃; for 0.5h; Inert atmosphere; microwave irradiation;

Reference yield:

: 5417-82-3
(1-ethoxyethylidene)malononitrile

: 1290137-71-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxamide

: 1290137-74-4
5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 0.33 h / 105 °C / microwave irradiation

2: diiodomethane; isopentyl nitrite / acetonitrile / 1 h / 50 °C

3: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; 1,2-dimethoxyethane / 0.5 h / 145 °C / Inert atmosphere; microwave irradiation

4: boron tribromide / dichloromethane / 20 °C

5: hydroxylamine hydrochloride; sodium hydrogencarbonate; water / methanol / 0.5 h / 130 °C / Inert atmosphere; microwave irradiation

With diiodomethane; hydroxylamine hydrochloride; water; boron tribromide; sodium hydrogencarbonate; isopentyl nitrite; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 10557-85-4
4-iodo-3,5-dimethylisoxazole

: 1290137-71-1
5-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-3-methyl-1H-pyrazole-4-carboxamide

: 1290137-74-4
5-(3,5-dimethylisoxazol-4-yl)-N'-hydroxy-1-(4-hydroxyphenyl)-3-methyl-4H-pyrazole-4-carboximidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane; 1,2-dimethoxyethane / 0.5 h / 145 °C / Inert atmosphere; microwave irradiation

3.1: boron tribromide / dichloromethane / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydrogencarbonate; water / methanol / 0.5 h / 130 °C / Inert atmosphere; microwave irradiation

With n-butyllithium; hydroxylamine hydrochloride; water; boron tribromide; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; hexane; dichloromethane;