(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

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Chemical Name:(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide
CAS No.:152032-92-3
Molecular Formula:C₁₈H₁₉N₃O₆
Molecular Weight:373.365
Hs Code.:

Synonyms:(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

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Chemical Property of (E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

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Technology Process of (E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

There total 10 articles about (E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 152032-91-2
(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

: 152032-92-3
(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)60643-3

Reference yield:

: 15865-57-3
2-nitro-3-methoxybenzoyl chloride

: 152032-92-3
(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent

2: 68 percent / iBu₂AlH / tetrahydrofuran; hexane

3: 83 percent

5: 87 percent / quinolinium camphorsulfonate / toluene / Heating

6: 87 percent / POCl₃

8: 1 N Ba(OH)2

9: 93 percent / (COCl)2, iPr₂NEt / dimethylsulfoxide

With barium dihydroxide; oxalyl dichloride; quinolinium camphor-10-sulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; hexane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(00)60643-3

Reference yield:

: 67040-46-4
(5S)-5-[(1-ethoxyethyl)oxymethyl]tetrahydro-1H-2-pyrrolone

: 152032-92-3
(E)-3-[(S)-5-Formyl-1-(3-methoxy-2-nitro-benzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethyl-acrylamide

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent

2: 68 percent / iBu₂AlH / tetrahydrofuran; hexane

3: 83 percent

5: 87 percent / quinolinium camphorsulfonate / toluene / Heating

6: 87 percent / POCl₃

8: 1 N Ba(OH)2

9: 93 percent / (COCl)2, iPr₂NEt / dimethylsulfoxide

With barium dihydroxide; oxalyl dichloride; quinolinium camphor-10-sulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; hexane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(00)60643-3