(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

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Chemical Name:(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide
CAS No.:152032-91-2
Molecular Formula:C₁₈H₂₁N₃O₆
Molecular Weight:375.381
Hs Code.:

Synonyms:(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

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Chemical Property of (E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

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Technology Process of (E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

There total 10 articles about (E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1233705-47-9
(E)-3-[(S)-5-((tert-butyldimethylsilyloxy)methyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

: 152032-91-2
(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

Guidance literature:: With hydrogenchloride; In methanol; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol101035p

Reference yield:

: 15865-57-3
2-nitro-3-methoxybenzoyl chloride

: 152032-91-2
(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent

2: 68 percent / iBu₂AlH / tetrahydrofuran; hexane

3: 83 percent

5: 87 percent / quinolinium camphorsulfonate / toluene / Heating

6: 87 percent / POCl₃

8: 1 N Ba(OH)2

With barium dihydroxide; quinolinium camphor-10-sulfonate; diisobutylaluminium hydride; trichlorophosphate; In tetrahydrofuran; hexane; toluene;
DOI:10.1016/S0040-4039(00)60643-3

Reference yield:

: 67040-46-4
(5S)-5-[(1-ethoxyethyl)oxymethyl]tetrahydro-1H-2-pyrrolone

: 152032-91-2
(E)-3-[(S)-5-(hydroxymethyl)-1-(3-methoxy-2-nitrobenzoyl)-4,5-dihydro-1H-pyrrol-3-yl]-N,N-dimethylacrylamide

Guidance literature:: Multi-step reaction with 8 steps

1: 95 percent

2: 68 percent / iBu₂AlH / tetrahydrofuran; hexane

3: 83 percent

5: 87 percent / quinolinium camphorsulfonate / toluene / Heating

6: 87 percent / POCl₃

8: 1 N Ba(OH)2

With barium dihydroxide; quinolinium camphor-10-sulfonate; diisobutylaluminium hydride; trichlorophosphate; In tetrahydrofuran; hexane; toluene;
DOI:10.1016/S0040-4039(00)60643-3