4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one

Base Information

• Chemical Name: 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one
• CAS No.: 37127-98-3
• Molecular Formula: C₁₉H₁₉NOS
• Molecular Weight: 309.432
• Mol file: 37127-98-3.mol

Synonyms:4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one

Chemical Property of 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one

There total 4 articles about 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) → 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one (37127-98-3)

Guidance literature:

1,2-di(4-methylphenyl)-1,2-ethanedione; 3-benzyl-4-methyl-1,3-thiazol-3-ium salt; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

With water; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c2ob25928a

Reference yield:

1,2-di(4-methylphenyl)-1,2-ethanedione (3457-48-5) + 3-Benzyl-4-methylthiazolium bromide (4356-66-5) → 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one (37127-98-3)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1039/c2ob25928a

Reference yield:

benzyl bromide (100-39-0) → 4-benzyl-5-methyl-2-(p-tolyl)-2,3-dihydro-4H-1,4-thiazin-3-one (37127-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 120 °C / Microwave irradiation

2: triethylamine / N,N-dimethyl-formamide / 2 h / 100 °C / Microwave irradiation

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1039/c2ob25928a

upstream raw materials:

diethyl (4-methylbenzoyl)phosphonate

3-(1-phenylmethyl)-4-methylthiazol-3-ium chloride

1,2-di(4-methylphenyl)-1,2-ethanedione

3-Benzyl-4-methylthiazolium bromide