4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 869478-41-1
• Molecular Formula: C₂₄H₄₀ClN₃O₃S
• Molecular Weight: 486.119

Synonyms:4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of 4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-{4-chloro-2-[(S)-3-methyl-1-((S_S)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

4-{4-chloro-2-[((SS)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (869478-26-2) + (2-methylpropyl)lithium (920-36-5,90269-51-5) → 4-{4-chloro-2-[(S)-3-methyl-1-((SS)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (869478-41-1) + 4-{4-chloro-2-[(R)-3-methyl-1-((SS)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:

With trimethylaluminum; In tetrahydrofuran; n-heptane; toluene; at -68 ℃; for 1h;

DOI:10.1021/jo051514p

Reference yield:

4-(4-chloro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (869478-16-0) → 4-{4-chloro-2-[(S)-3-methyl-1-((SS)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (869478-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / Ti(OEt)4 / tetrahydrofuran; ethanol / 16 h / 20 °C

2: 65 percent / Me₃Al / tetrahydrofuran; heptane; toluene / 1 h / -68 °C

With titanium(IV) tetraethanolate; trimethylaluminum; In tetrahydrofuran; ethanol; n-heptane; toluene;

DOI:10.1021/jo051514p

Reference yield:

5-chloro-2-fluorobenzaldehyde (96515-79-6) → 4-{4-chloro-2-[(S)-3-methyl-1-((SS)-2-methyl-propane-2-sulfinylamino)-butyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester (869478-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 13 percent / K₂CO₃ / dimethylformamide / 16 h / 100 °C

2: 91 percent / Ti(OEt)4 / tetrahydrofuran; ethanol / 16 h / 20 °C

3: 65 percent / Me₃Al / tetrahydrofuran; heptane; toluene / 1 h / -68 °C

With titanium(IV) tetraethanolate; trimethylaluminum; potassium carbonate; In tetrahydrofuran; ethanol; n-heptane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo051514p

upstream raw materials:

4-{4-chloro-2-[((S_S)-2-methyl-propane-2-sulfinylimino)-methyl]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester

(2-methylpropyl)lithium

4-(4-chloro-6-formyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

5-chloro-2-fluorobenzaldehyde

Downstream raw materials:

4-{2-[(1S)-((S)-tert-butanesulfinylamino)-3-methylbutyl]-4-chlorophenyl}-1-piperazine

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