4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

Base Information

• Chemical Name: 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid
• CAS No.: 913987-14-1
• Molecular Formula: C₂₅H₂₂O₇S
• Molecular Weight: 466.511
• Mol file: 913987-14-1.mol

Synonyms:4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

Chemical Property of 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

There total 6 articles about 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(9H-fluoren-9-yl)methyl 4-benzyl-2-(4-methoxyphenylsulfonyl)succinate (913987-13-0) → 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid (913987-14-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1039/b609446e

Reference yield:

4-Methoxybenzenethiol (696-63-9) → 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid (913987-14-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 84 percent / t-BuOK / 3 h

2: 77 percent / NaHMDS / tetrahydrofuran

3: 76 percent / m-CPBA / CH₂Cl₂

4: 98 percent / TFA / CH₂Cl₂

5: 95 percent / DCC; DMAP / CH₂Cl₂

6: 94 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

With dmap; potassium tert-butylate; hydrogen; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b609446e

Reference yield:

4-benzyl 1-tert-butyl 2-(4-methoxyphenylthio)succinate (913987-10-7) → 4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid (913987-14-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / m-CPBA / CH₂Cl₂

2: 98 percent / TFA / CH₂Cl₂

3: 95 percent / DCC; DMAP / CH₂Cl₂

4: 94 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

With dmap; hydrogen; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b609446e

upstream raw materials:

1-(9H-fluoren-9-yl)methyl 4-benzyl-2-(4-methoxyphenylsulfonyl)succinate

4-(benzyloxy)-2-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

4-benzyl 1-tert-butyl 2-(4-methoxyphenylthio)succinate

4-benzyl 1-tert-butyl 2-(4-methoxyphenylsulfonyl)succinate

Downstream raw materials:

(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

2-(4-methoxyphenylsulfonyl)-4-oxo-4-(trityloxyamino)butanoic acid