(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

Base Information

Chemical Name:(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate
CAS No.:913987-15-2
Molecular Formula:C₄₄H₃₇NO₇S
Molecular Weight:723.846
Hs Code.:

Synonyms:(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

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Chemical Property of (9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

Chemical Property:

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Technology Process of (9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

There total 7 articles about (9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 913987-14-1
4-((9H-fluoren-9-yl)methoxy)-3-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

: 31938-11-1
O-tritylhydroxylamine

: 913987-15-2
(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1039/b609446e

Reference yield:

: 696-63-9
4-Methoxybenzenethiol

: 913987-15-2
(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / t-BuOK / 3 h

2: 77 percent / NaHMDS / tetrahydrofuran

3: 76 percent / m-CPBA / CH₂Cl₂

4: 98 percent / TFA / CH₂Cl₂

5: 95 percent / DCC; DMAP / CH₂Cl₂

6: 94 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

7: 73 percent / DCC / CH₂Cl₂

With dmap; potassium tert-butylate; hydrogen; sodium hexamethyldisilazane; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b609446e

Reference yield:

: 913987-12-9
4-(benzyloxy)-2-(4-methoxyphenylsulfonyl)-4-oxobutanoic acid

: 913987-15-2
(9H-fluoren-9-yl)methyl 2-(4-methoxyphenylsulfonyl)-4-(trityloxyamino)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / DCC; DMAP / CH₂Cl₂

2: 94 percent / H₂ / Pd/C / tetrahydrofuran / 1.5 h / 20 °C

3: 73 percent / DCC / CH₂Cl₂

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b609446e