N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Base Information

Chemical Name:N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide
CAS No.:1425782-76-8
Molecular Formula:C₂₅H₂₄N₄O*H₃O₄P
Molecular Weight:494.487
Hs Code.:

Synonyms:N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Suppliers and Price of N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

There total 8 articles about N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 875002-69-0
N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

: 1425782-76-8
N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Guidance literature:: With phosphoric acid; In ethanol; at 20 - 78 ℃; for 5h; Inert atmosphere;
DOI:10.1055/s-0032-1317554

Reference yield:

: 3230-65-7
3,4-dihydroisoquinoline

: 1425782-76-8
N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium nitrate / sulfuric acid / 2 h / 20 - 40 °C / Inert atmosphere

2: manganese(IV) oxide / 18 h / 103 °C / Inert atmosphere

3: hydrogen; palladium 10% on activated carbon / ethanol / 5 h

4: lithium hexamethyldisilazane / tetrahydrofuran / 7 h / 40 - 70 °C / Inert atmosphere

5: phosphoric acid / ethanol / 5 h / 20 - 78 °C / Inert atmosphere

With manganese(IV) oxide; phosphoric acid; palladium 10% on activated carbon; hydrogen; potassium nitrate; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; sulfuric acid;
DOI:10.1055/s-0032-1317554

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1425782-76-8
N-(4-isopropyl-3-methylphenyl)-2-(isoquinolin-7-ylamino)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide; N-Bromosuccinimide / dichloromethane / Inert atmosphere

2: potassium nitrate / sulfuric acid / 2 h / 20 - 40 °C / Inert atmosphere

3: manganese(IV) oxide / 18 h / 103 °C / Inert atmosphere

4: hydrogen; palladium 10% on activated carbon / ethanol / 5 h

5: lithium hexamethyldisilazane / tetrahydrofuran / 7 h / 40 - 70 °C / Inert atmosphere

6: phosphoric acid / ethanol / 5 h / 20 - 78 °C / Inert atmosphere

With manganese(IV) oxide; N-Bromosuccinimide; phosphoric acid; palladium 10% on activated carbon; hydrogen; potassium nitrate; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; sulfuric acid;
DOI:10.1055/s-0032-1317554