[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane
CAS No.:333788-69-5
Molecular Formula:C₂₀H₃₂O₂Si
Molecular Weight:332.558
Hs Code.:

Synonyms:[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

Chemical Property:

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Technology Process of [(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

There total 11 articles about [(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 333788-81-1
(4R,5S)-5-Benzyloxy-hept-1-yn-4-ol

: 333788-69-5
[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With pyridine; silver nitrate; In acetonitrile;
DOI:10.1016/S0040-4039(00)02281-4

Reference yield:

: 84379-53-3
2-O-benzyl-3,4-O-isopropylidene-L-threitol

: 333788-69-5
[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / TEA; DMAP / CH₂Cl₂

2: 93 percent / diethyl ether / -65 - 0 °C

3: 97 percent / PPTS / ethanol / 80 °C

4: 100 percent / TEA; DMAP / CH₂Cl₂ / 60 °C

5: 98 percent / TEA; DMAP / CH₂Cl₂

6: 96 percent / TBAF / tetrahydrofuran

7: 93 percent / EDA / dimethylsulfoxide / 0 °C

8: 98 percent / AgNO₃; pyridine / acetonitrile

With pyridine; diazoacetic acid ethyl ester; dmap; TEA; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; silver nitrate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)02281-4

Reference yield:

: 131446-96-3
(S)-2-(benzyloxy)-2-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl 4-methylbenzenesulfonate

: 333788-69-5
[(R)-1-((S)-1-Benzyloxy-propyl)-but-3-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / diethyl ether / -65 - 0 °C

2: 97 percent / PPTS / ethanol / 80 °C

3: 100 percent / TEA; DMAP / CH₂Cl₂ / 60 °C

4: 98 percent / TEA; DMAP / CH₂Cl₂

5: 96 percent / TBAF / tetrahydrofuran

6: 93 percent / EDA / dimethylsulfoxide / 0 °C

7: 98 percent / AgNO₃; pyridine / acetonitrile

With pyridine; diazoacetic acid ethyl ester; dmap; TEA; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; silver nitrate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0040-4039(00)02281-4