3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

Base Information

Chemical Name:3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose
CAS No.:302582-09-8
Molecular Formula:C₁₆H₂₀N₂O₄
Molecular Weight:304.346
Hs Code.:

Synonyms:3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

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Chemical Property of 3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

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Technology Process of 3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

There total 4 articles about 3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 23202-83-7,2592-42-9
5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose

: 7677-24-9
trimethylsilyl cyanide

: 302582-09-8
3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

Guidance literature:: 5-benzyl-1,2-O-isopropylidene-α-D-xylofuranose; With dipyridinium dichromate; acetic anhydride; In dichloromethane; Molecular sieve; Reflux;

With titanium(IV) isopropylate; ammonia; In methanol;

trimethylsilyl cyanide; In methanol;
DOI:10.1016/j.tet.2013.04.043

Reference yield: 41.0%

: 667923-22-0
Ethanesulfonic acid ((3aR,5S,6R,6aR)-5-benzyloxymethyl-6-cyano-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl)-amide

: 302582-09-8
3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

: C₁₈H₂₄N₂O₆S

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; for 2h;
DOI:10.1021/jo035301g

Reference yield:

: 34311-63-2
5-O-benzyl-3-oxo-1,2-O-isopropylidene-α-D-xylofuranose

: 302582-09-8
3-amino-5-O-benzyl-3-C-cyano-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃; Ti(OiPr)4 / methanol / 20 °C

2: methanol / 12 h

With titanium(IV) isopropylate; ammonia; In methanol; 1: amination / 2: cyanation;
DOI:10.1016/S0040-4039(00)01090-X