(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:959691-69-1
Molecular Formula:C₂₀H₁₆F₃N₃O₃
Molecular Weight:403.361
Hs Code.:

Synonyms:(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 8 articles about (R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 959694-09-8
(R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 74-88-4
methyl iodide

: 959691-69-1
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: (R)-4-[2,5-dioxo-4-(4-methoxyphenyl)-4-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

: 22927-78-2
5-(4-methoxyphenyl)-5-methyl-2,4-imidazolidinedione

: 959691-69-1
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / 64 h / Inert atmosphere; Reflux

2.1: (R)-1-phenyl-ethyl-amine / ethanol / 20 - 40 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / pH 1 / Inert atmosphere

3.1: hydrogenchloride / 3 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / 0 °C / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; (R)-1-phenyl-ethyl-amine; sodium hydride; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300249m

Reference yield:

: 143782-18-7
4-isocyanato-2-(trifluoromethyl)benzonitrile

: 959691-69-1
(R)-4-[3,4-dimethyl-2,5-dioxo-4-(4-methoxyphenyl)imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm300249m