Technology Process of 1-chloro-3,3-dimethylcyclobutyl p-tolylsulfoxide
There total 8 articles about 1-chloro-3,3-dimethylcyclobutyl p-tolylsulfoxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-chloro-succinimide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 5h;
DOI:10.1055/s-0031-1291011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / -50 - 15 °C
2: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 0 °C / Reflux
3: triethylamine / tetrahydrofuran / 2.08 h / -78 - -15 °C
4: sodium tetrahydroborate / 1,3-dimethyl-2-imidazolidinone / 1.5 h / 0 - 100 °C
5: N-chloro-succinimide / tetrahydrofuran / 5 h / 0 - 20 °C
With
sodium tetrahydroborate; N-chloro-succinimide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,3-dimethyl-2-imidazolidinone; methanol; chloroform;
DOI:10.1055/s-0031-1291011
- Guidance literature:
-
Multi-step reaction with 8 steps
1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr
2: dmap; triethylamine / chloroform / 3.5 h / 0 °C
3: potassium tert-butylate / tert-butyl alcohol / 15 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / -50 - 15 °C
5: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 0 °C / Reflux
6: triethylamine / tetrahydrofuran / 2.08 h / -78 - -15 °C
7: sodium tetrahydroborate / 1,3-dimethyl-2-imidazolidinone / 1.5 h / 0 - 100 °C
8: N-chloro-succinimide / tetrahydrofuran / 5 h / 0 - 20 °C
With
dmap; sodium tetrahydroborate; N-chloro-succinimide; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; 1,3-dimethyl-2-imidazolidinone; methanol; chloroform; ethyl acetate; tert-butyl alcohol;
DOI:10.1055/s-0031-1291011
