diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

Base Information

Chemical Name:diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate
CAS No.:1400273-63-3
Molecular Formula:C₁₇H₂₂O₄S
Molecular Weight:322.425
Hs Code.:

Synonyms:diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

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Technology Process of diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

There total 3 articles about diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 825620-41-5
diethyl 3-(p-toluenesulfonyloxy)cyclobutane-1,1-dicarboxylate

: 106-45-6
para-thiocresol

: 1400273-63-3
diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 15h; Reflux;
DOI:10.1055/s-0031-1291011

Reference yield:

: 99974-66-0
diethyl 3-hydroxycyclobutane-1,1-dicarboxylate

: 1400273-63-3
diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / chloroform / 3.5 h / 0 °C

2: potassium tert-butylate / tert-butyl alcohol / 15 h / Reflux

With dmap; potassium tert-butylate; triethylamine; In chloroform; tert-butyl alcohol;
DOI:10.1055/s-0031-1291011

Reference yield:

: 54166-15-3
diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

: 1400273-63-3
diethyl 3-(p-tolylthio)cyclobutane-1,1-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr

2: dmap; triethylamine / chloroform / 3.5 h / 0 °C

3: potassium tert-butylate / tert-butyl alcohol / 15 h / Reflux

With dmap; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triethylamine; In chloroform; ethyl acetate; tert-butyl alcohol;
DOI:10.1055/s-0031-1291011