3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

Base Information

Chemical Name:3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide
CAS No.:1400273-65-5
Molecular Formula:C₁₃H₁₈O₃S
Molecular Weight:254.35
Hs Code.:

Synonyms:3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

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Chemical Property of 3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

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Technology Process of 3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

There total 5 articles about 3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1400273-64-4
diethyl 3-(p-tolylsulfinyl)cyclobutane-1,1-dicarboxylate

: 1400273-65-5
3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 2.5h; Reflux;
DOI:10.1055/s-0031-1291011

Reference yield:

: 54166-15-3
diethyl 3-(benzyloxy)cyclobutane-1,1-dicarboxylate

: 1400273-65-5
3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 20 °C / 760.05 Torr

2: dmap; triethylamine / chloroform / 3.5 h / 0 °C

3: potassium tert-butylate / tert-butyl alcohol / 15 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / -50 - 15 °C

5: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 0 °C / Reflux

With dmap; sodium tetrahydroborate; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; chloroform; ethyl acetate; tert-butyl alcohol;
DOI:10.1055/s-0031-1291011

Reference yield:

: 825620-41-5
diethyl 3-(p-toluenesulfonyloxy)cyclobutane-1,1-dicarboxylate

: 1400273-65-5
3,3-bis(hydroxymethyl)cyclobutyl p-tolylsulfoxide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tert-butyl alcohol / 15 h / Reflux

2: 3-chloro-benzenecarboperoxoic acid / chloroform / 5 h / -50 - 15 °C

3: sodium tetrahydroborate / tetrahydrofuran; methanol / 2.5 h / 0 °C / Reflux

With sodium tetrahydroborate; potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; chloroform; tert-butyl alcohol;
DOI:10.1055/s-0031-1291011