N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

Base Information

Chemical Name:N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide
CAS No.:1613169-19-9
Molecular Formula:C₂₈H₃₇BF₃N₃O₄
Molecular Weight:547.426
Hs Code.:

Synonyms:N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

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Chemical Property of N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

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Technology Process of N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

There total 3 articles about N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613169-00-8
2-(4-bromophenoxy)-N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}acetamide

: 73183-34-3
bis(pinacol)diborane

: 1613169-19-9
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; for 10h; Inert atmosphere; Reflux;

Reference yield:

: 1878-91-7
(4-bromophenoxy)acetic acid

: 1613169-19-9
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; oxalyl dichloride; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 16738-06-0
4-bromophenoxyacetyl chloride

: 1613169-19-9
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2-[4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 10 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; In 1,4-dioxane; dichloromethane;