Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

Base Information

Chemical Name:Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester
CAS No.:189748-70-7
Molecular Formula:C₁₈H₂₈O₄SSi
Molecular Weight:368.569
Hs Code.:

Synonyms:Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

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Chemical Property of Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

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Technology Process of Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

There total 7 articles about Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 189748-68-3
Benzoic acid (2R,3S,4S)-4-hydroxy-2-hydroxymethyl-tetrahydro-thiophen-3-yl ester

: 189748-70-7
Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jo9700540

Reference yield:

: 160882-25-7
3-O-benzyl-1-deoxy-4-thio-D-arabino-furanose

: 189748-70-7
Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / imidazole / dimethylformamide / Ambient temperature

2: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

3: BCl₃ / CH₂Cl₂ / 6.5 h / -78 °C

4: 4.01 g / triethylamine, 4-(dimethylamino)pyridine / acetonitrile / 5 h / Ambient temperature

5: 89 percent / NH₄F*HF / methanol / 43 h / Ambient temperature

6: 80 percent / imidazole / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; dmap; ammonium fluoride; hydrogen fluoride; boron trichloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo9700540

Reference yield:

: 174833-54-6
(3S,4S,5R)-4-Benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

: 189748-70-7
Benzoic acid (2R,3S,4S)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-hydroxy-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

2: BCl₃ / CH₂Cl₂ / 6.5 h / -78 °C

3: 4.01 g / triethylamine, 4-(dimethylamino)pyridine / acetonitrile / 5 h / Ambient temperature

4: 89 percent / NH₄F*HF / methanol / 43 h / Ambient temperature

5: 80 percent / imidazole / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; dmap; ammonium fluoride; hydrogen fluoride; boron trichloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo9700540