Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

Base Information

• Chemical Name: Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide
• CAS No.: 1268830-77-8
• Molecular Formula: C₉H₁₂ClFN₂O₂S
• Molecular Weight: 266.724
• Mol file: 1268830-77-8.mol

Synonyms:Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

Chemical Property of Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

There total 6 articles about Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-6-fluoro-3-(propylsulfonamido)benzoic acid (1186194-00-2) → Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide (1268830-77-8)

Guidance literature:

2-chloro-6-fluoro-3-(propylsulfonamido)benzoic acid; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 20 - 80 ℃; for 5h; Inert atmosphere;

With water; In tetrahydrofuran; at 80 ℃; for 2h;

DOI:10.1021/jm300016v

Reference yield:

methyl 2-chloro-3-(2,5-dimethyl-1H-pyrrol-1-yl)-6-fluorobenzoate (1268830-73-4) → Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide (1268830-77-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 18 h / Reflux; Inert atmosphere

2.1: triethylamine / dichloromethane / 1.33 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: water; potassium hydroxide / tetrahydrofuran; water / 2 h / Reflux; Inert atmosphere

4.1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 5 h / 20 - 80 °C / Inert atmosphere

4.2: 2 h / 80 °C

With diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1021/jm300016v

Reference yield:

2-chloro-4-fluoroaniline (2106-02-7) → Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide (1268830-77-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 1 h / Reflux; Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

2.2: 2.5 h / -78 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; triethylamine / ethanol; water / 18 h / Reflux; Inert atmosphere

4.1: triethylamine / dichloromethane / 1.33 h / 0 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: water; potassium hydroxide / tetrahydrofuran; water / 2 h / Reflux; Inert atmosphere

6.1: diphenyl phosphoryl azide; triethylamine / tetrahydrofuran / 5 h / 20 - 80 °C / Inert atmosphere

6.2: 2 h / 80 °C

With n-butyllithium; diphenyl phosphoryl azide; hydroxylamine hydrochloride; water; toluene-4-sulfonic acid; triethylamine; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

DOI:10.1021/jm300016v

upstream raw materials:

2-chloro-6-fluoro-3-(propylsulfonamido)benzoic acid

1-(2-chloro-4-fluorophenyl)-2,5-dimethyl-1H-pyrrole

methyl 2-chloro-3-(2,5-dimethyl-1H-pyrrol-1-yl)-6-fluorobenzoate

methyl 2-chloro-6-fluoro-3-(propylsulfonamido)benzoate

Downstream raw materials:

N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

4-aminothieno[3,2-d]pyrimidine-7-carboxylic acid [2-chloro-6-fluoro-3-(propane-1-sulfonylamino)phenyl]amide

N-(2-chloro-4-fluoro-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)propane-1-sulfonamide

N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide