N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

Base Information

• Chemical Name: N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide
• CAS No.: 1269421-49-9
• Molecular Formula: C₁₇H₂₀ClFN₂O₃S
• Molecular Weight: 386.875
• Mol file: 1269421-49-9.mol

Synonyms:N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

Chemical Property of N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

There total 1 articles about N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide (1268830-77-8) + p-methoxybenzyl chloride (824-94-2) → N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide (1269421-49-9)

Guidance literature:

Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 - 40 ℃; for 3.75h; Cooling with ice;

p-methoxybenzyl chloride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 14.0833h;

Reference yield: 70.0%

N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide (1269421-49-9) + 6-bromo-3,5-dimethylquinazolin-4(3H)-one → N-(2-chloro-3-((3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 90 ℃; Sealed tube;

Reference yield: 31.0%

methyl 4-chloro-6-methylquinazoline-8-carboxylate (1269421-66-0) + N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide (1269421-49-9) → 4-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-6-methylquinazoline-8-carboxamide (1269421-96-6)

Guidance literature:

N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide; With trimethylaluminum; In hexane; toluene; at 20 ℃; for 1h;

methyl 4-chloro-6-methylquinazoline-8-carboxylate; In hexane; toluene; at 80 ℃; for 48h;

With water; Rochelle's salt; In hexane; toluene; at 20 ℃; for 1h;

upstream raw materials:

Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

p-methoxybenzyl chloride

Downstream raw materials:

N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-2-cyano-3-fluoroisonicotinamide

4-amino-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)pyrido[3,2-d]pyrimidine-8-carboxamide

4-amino-N-(2-chloro-6-fluoro-3-(propylsulfonamido)phenyl)-pyrido[3,2-d]pyrimidine-8-carboxamide

4-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)(propylsulfonamido))phenyl)-6-methylquinazoline-8-carboxamide