N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide

Base Information

• Chemical Name: N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide
• CAS No.: 1269667-70-0
• Molecular Formula: C₂₅H₂₄ClFN₄O₄S₂
• Molecular Weight: 563.073
• Mol file: 1269667-70-0.mol

Synonyms:N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property of N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide

There total 5 articles about N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate (1246223-44-8) + N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide (1269421-49-9) + trimethylaluminum (75-24-1) → 4-chloro-N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)thieno[3,2-d]pyrimidine-7-carboxamide (1269667-69-7) + N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide (1269667-70-0)

Guidance literature:

N-(3-amino-2-chloro-4-fluorophenyl)-N-(4-methoxybenzyl)propane-1-sulfonamide; trimethylaluminum; In hexane; toluene; at 20 ℃; for 1.33333h;

methyl 4-chlorothieno[3,2-d]pyrimidine-7-carboxylate; In hexane; toluene; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

7-bromothieno[3,2-d]pyrimidine-4(3H)-one (31169-25-2) → N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide (1269667-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

2.1: trichlorophosphate / 2 h / Reflux

2.2: Cooling with ice

3.1: toluene; hexane / 1.33 h / 20 °C

3.2: 4 h / 80 °C / Inert atmosphere

With triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In hexane; toluene;

Reference yield:

3H-thieno[3,2-d]pyrimidin-4-one (16234-10-9) → N-(2-chloro-6-fluoro-3-(N-(4-methoxybenzyl)propylsulfonamido)phenyl)-4-methylthieno[3,2-d]pyrimidine-7-carboxamide (1269667-70-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / acetic acid / 8 h / 100 °C

1.2: 20 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 3 h / 120 °C / 15514.9 Torr / Autoclave

3.1: trichlorophosphate / 2 h / Reflux

3.2: Cooling with ice

4.1: toluene; hexane / 1.33 h / 20 °C

4.2: 4 h / 80 °C / Inert atmosphere

With bromine; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In hexane; acetic acid; toluene;

upstream raw materials:

Ν-(2-chloro-3-amino-4-fluorophenyl)-1-propyl sulfonamide

p-methoxybenzyl chloride

3H-thieno[3,2-d]pyrimidin-4-one

7-bromothieno[3,2-d]pyrimidine-4(3H)-one