N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

Base Information

Chemical Name:N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide
CAS No.:1421373-67-2
Molecular Formula:C₂₉H₃₂N₈O₂
Molecular Weight:524.625
Hs Code.:

Synonyms:N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

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Chemical Property of N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

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Technology Process of N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

There total 7 articles about N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1421372-68-0
2-{[5-amino-4-(2-dimethylaminoethyl-methylamino)-2-methoxyphenyl]amino}-4-(1-methylindol-3-yl)pyrimidine-5-carbonitrile

: 814-68-6,25189-84-8
acryloyl chloride

: 1421373-67-2
N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

: 1421373-67-2
N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / 18 h / 125 °C

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 0.5 h / 140 °C / Microwave irradiation

4.1: iron; ammonium chloride / water; ethanol / 1.5 h / Reflux

5.1: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl acetamide / 3.5 h / 95 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iron; sodium hydride; ammonium chloride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; zinc; XPhos; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 1421372-63-5
N⁴-[5-chloro-4-(1-methylindol-3-yl)pyrimidin-2-yl]-N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methylbenzene-1,2,4-triamine

: 1421373-67-2
N-[5-[[5-cyano-4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-(2-dimethylaminoethylmethylamino)-4-methoxyphenyl]prop-2-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl acetamide / 3.5 h / 95 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; zinc; XPhos; In dichloromethane; N,N-dimethyl acetamide;