benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

Base Information

Chemical Name:benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate
CAS No.:1438250-68-0
Molecular Formula:C₃₀H₂₃F₃N₄O₃
Molecular Weight:544.533
Hs Code.:

Synonyms:benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

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Chemical Property of benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

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Technology Process of benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

There total 7 articles about benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1370534-54-5
2-(6-bromopyridin-3-yl)-5-(trifluoromethyl)-1H-benzimidazole

: 1438249-52-5
benzyl 3-{[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]oxy}cyclobutanecarboxylate

: 1438250-68-0
benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1438250-68-0
benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 1 h / 0 °C

2: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With methanol; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 23761-23-1
3-oxocyclobutanecarboxylic acid

: 1438250-68-0
benzyl 3-({5-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-2,3'-bipyridin-6'-yl}oxy)cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 1 h / 0 °C

2: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 48 h / 55 °C / Inert atmosphere

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With methanol; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;