BENZYL 3-OXOCYCLOBUTANECARBOXYLATE

Base Information

• Chemical Name: BENZYL 3-OXOCYCLOBUTANECARBOXYLATE
• CAS No.: 198995-91-4
• Molecular Formula: C12H12O3
• Molecular Weight: 204.225
• Hs Code.: 2918300090
• Mol file: 198995-91-4.mol

Synonyms:Benzyl 3-oxocyclobutanecarboxylate;3-OXO-CYCLOBUTANECARBOXYLIC ACID BENZYL ESTER;3-oxocyclobutane carboxylic benzyl ester;

Chemical Property of BENZYL 3-OXOCYCLOBUTANECARBOXYLATE

Chemical Property:

• Boiling Point: 324.9±35.0 °C(Predicted)
• PSA: 43.37000
• Density: 1.231
• LogP: 1.70890
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Benzyl3-Oxocyclobutanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL 3-OXOCYCLOBUTANECARBOXYLATE

There total 6 articles about BENZYL 3-OXOCYCLOBUTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-oxocyclobutanecarboxylic acid (23761-23-1) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 3-oxocyclobutane-1-carboxylate (198995-91-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; for 1h; Solvent; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.joc.1c00970

Reference yield: 100.0%

3-oxocyclobutanecarboxylic acid (23761-23-1) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 3-oxocyclobutane-1-carboxylate (198995-91-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield: 93.0%

3-oxocyclobutanecarboxylic acid (23761-23-1) + benzyl bromide (100-39-0) → benzyl 3-oxocyclobutane-1-carboxylate (198995-91-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 60h; Cooling with ice;

DOI:10.1021/ml500341w

upstream raw materials:

3-oxocyclobutanecarboxylic acid

benzyl bromide

benzyl alcohol

benzyl chloroformate

Downstream raw materials:

benzyl 3,3-difluorocyclobutane-1-carboxylate

cis-benzyl 3-hydroxycyclobutanecarboxylate

trans-benzyl 3-hydroxycyclobutanecarboxylate

benzyl 3-[(5-bromopyridin-2-yl)oxy]cyclobutanecarboxylate