1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Base Information

Chemical Name:1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione
CAS No.:1608154-39-7
Molecular Formula:C₂₆H₃₃FN₄O₂
Molecular Weight:452.572
Hs Code.:

Synonyms:1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

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Chemical Property of 1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

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Technology Process of 1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

There total 4 articles about 1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1608154-32-0
C₁₆H₂₁BrN₂O₂

: 1011-15-0
1-(o-fluorophenyl)piperazine

: 1608154-39-7
1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Guidance literature:: 1-(o-fluorophenyl)piperazine; With potassium carbonate; In acetone; for 0.25h; Reflux;

C₁₆H₂₁BrN₂O₂; In acetone; at 45 - 58 ℃; Microwave irradiation;
DOI:10.1016/j.ejmech.2014.01.065

Reference yield:

: 6843-49-8,27539-12-4,99571-24-1,101693-73-6
5-methyl-5-phenylimidazolidin-2,4-dione

: 1608154-39-7
1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / Reflux

2.1: potassium carbonate / acetone / 20 °C

3.1: potassium carbonate / acetone / 0.25 h / Reflux

3.2: 45 - 58 °C / Microwave irradiation

With sodium ethanolate; potassium carbonate; In acetone;
DOI:10.1016/j.ejmech.2014.01.065

Reference yield:

: 98-86-2
acetophenone

: 1608154-39-7
1-(5-(4-(2-fluorophenyl)piperazin-1-yl)pentyl)-3,5-dimethyl-5-phenylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium carbonate / ethanol / 55 °C

2.1: sodium ethanolate / Reflux

3.1: potassium carbonate / acetone / 20 °C

4.1: potassium carbonate / acetone / 0.25 h / Reflux

4.2: 45 - 58 °C / Microwave irradiation

With sodium ethanolate; ammonium carbonate; potassium carbonate; In ethanol; acetone; 1.1: |Bucherer-Bergs Reaction;
DOI:10.1016/j.ejmech.2014.01.065