4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

Base Information

Chemical Name:4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate
CAS No.:1361391-87-8
Molecular Formula:C₂₀H₂₂F₂O₆S₂
Molecular Weight:460.52
Hs Code.:

Synonyms:4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

Chemical Property:

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Technology Process of 4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

There total 7 articles about 4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1361391-81-2
4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexanol

: 124-63-0
methanesulfonyl chloride

: 1361391-87-8
4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 4-(benzyloxy)cyclohexyl methanesulfonate

: 1361391-87-8
4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

2: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 150 °C / Microwave irradiation

3: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With hydrogen; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2976-80-9
4-(benzyloxy)cyclohexan-1-ol

: 1361391-87-8
4-(3,5-difluoro-4'-(methylsulfonyl)biphenyl-4-yloxy)cyclohexyl methanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 2 h / 90 °C

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.17 h / 150 °C / Microwave irradiation

4: hydrogen / palladium 10% on activated carbon / methanol / 20 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With hydrogen; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;