N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Base Information

• Chemical Name: N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea
• CAS No.: 917389-24-3
• Molecular Formula: C₁₅H₁₂F₄N₂O₂
• Molecular Weight: 328.266
• Mol file: 917389-24-3.mol

Synonyms:N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Chemical Property of N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

There total 1 articles about N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

2-Fluoroaniline (348-54-9) + 2-methoxy-5-trifluoromethylphenyl isocyanate (16588-75-3) → N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea (917389-24-3)

Guidance literature:

In acetonitrile; at 82 ℃; for 4h;

Reference yield: 72.2%

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea (917389-24-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate (917389-26-5)

Guidance literature:

With sulfuric acid; acetic acid; palladium diacetate; at 20 ℃;

Reference yield: 65.0%

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea (917389-24-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl-(2Z)-3-[3-fluoro-2-({[2-methoxy-5-(trifluoromethyl)phenyl]carbamoyl}amino)-phenyl]acrylate

Guidance literature:

With sulfuric acid; sulfur trioxide; oxygen; palladium diacetate; acetic acid; at 20 ℃; for 20h; Inert atmosphere; Large scale;

upstream raw materials:

2-Fluoroaniline

2-methoxy-5-trifluoromethylphenyl isocyanate

Downstream raw materials:

methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

methyl 2-[8-fluoro-3-[2-methoxy-5-(trifluoromethyl)phenyl]-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-yl] acetate