methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate

Base Information

• Chemical Name: methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate
• CAS No.: 917389-26-5
• Molecular Formula: C₁₉H₁₆F₄N₂O₄
• Molecular Weight: 412.341
• Mol file: 917389-26-5.mol

Synonyms:methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate

Chemical Property of methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate

There total 5 articles about methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.2%

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea (917389-24-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate (917389-26-5)

Guidance literature:

With sulfuric acid; acetic acid; palladium diacetate; at 20 ℃;

Reference yield:

2-Fluoroaniline (348-54-9) → methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate (917389-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 4 h / 82 °C

2: sulfuric acid; acetic acid / palladium diacetate / 20 °C

With sulfuric acid; acetic acid; palladium diacetate; In acetonitrile;

Reference yield:

2-methoxy-5-trifluoromethylphenyl isocyanate (16588-75-3) → methyl-(E)-3-(3-fluoro-2-(3-(2-methoxy-5-(trifluoromethyl)phenyl)ureido)phenyl)acrylate (917389-26-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 4 h / 82 °C

2: sulfuric acid; acetic acid / palladium diacetate / 20 °C

With sulfuric acid; acetic acid; palladium diacetate; In acetonitrile;

upstream raw materials:

N-(2-fluorophenyl)-N'-[2-methoxy-5-(trifluoromethyl)phenyl]urea

acrylic acid methyl ester

methyl (2E)-3-(2-amino-3-fluorophenyl)acrylate

2-bromo-6-fluoroaniline

Downstream raw materials:

methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-oxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetate

(S)-2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)-phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetic acid

(R)-methyl 2-(8-fluoro-3-(2-methoxy-5-(trifluoromethyl)phenyl)-2-(4-(3-methoxyphenyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-yl)acetate