(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate
CAS No.:1449475-60-8
Molecular Formula:C₃₉H₄₄N₄O₃
Molecular Weight:616.803
Hs Code.:

Synonyms:(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

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Chemical Property of (S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

Chemical Property:

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Technology Process of (S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

There total 5 articles about (S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-neopentylbenzene-1,2-diamine: 1449475-58-4
4-neopentylbenzene-1,2-diamine

: 132388-68-2
N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine

(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate: 1449475-60-8
(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

Guidance literature:: N^α-tert-butoxycarbonyl-N^ω-triphenylmethyl-L-asparagine; With 4-methyl-morpholine; isobutyl chloroformate; In acetonitrile; for 0.75h; Cooling with ice;

4-neopentylbenzene-1,2-diamine; In acetonitrile; at 20 ℃; for 2.5h;

With acetic acid; for 18h;

Reference yield:

: 38896-18-3
N-(4-neopentyl-2-nitrophenyl)acetamide

(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate: 1449475-60-8
(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / 36 h / 90 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol / 3.5 h / 2068.65 Torr

3.1: 4-methyl-morpholine; isobutyl chloroformate / acetonitrile / 0.75 h / Cooling with ice

3.2: 2.5 h / 20 °C

3.3: 18 h

With 4-methyl-morpholine; palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; isobutyl chloroformate; In methanol; acetonitrile;

Reference yield:

: 38896-19-4
4-neopentyl-2-nitrobenzenamine

(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate: 1449475-60-8
(S)-tert-butyl (1-(5-neopentyl-1H-benzo[d]imidazol-2-yl)-3-oxo-3-(tritylamino)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 3.5 h / 2068.65 Torr

2.1: 4-methyl-morpholine; isobutyl chloroformate / acetonitrile / 0.75 h / Cooling with ice

2.2: 2.5 h / 20 °C

2.3: 18 h

With 4-methyl-morpholine; palladium 10% on activated carbon; hydrogen; isobutyl chloroformate; In methanol; acetonitrile;