1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

Base Information

Chemical Name:1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole
CAS No.:1448816-36-1
Molecular Formula:C₃₁H₃₀N₄O₆
Molecular Weight:554.602
Hs Code.:

Synonyms:1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

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Chemical Property of 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

Chemical Property:

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Technology Process of 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

There total 12 articles about 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₀ClNO₆

: 1448816-36-1
1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 60 ℃; for 4h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.06.004

Reference yield:

: 100-39-0
benzyl bromide

: 1448816-36-1
1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

2: tin(II) chloride dihdyrate / ethyl acetate / 20 h / 60 °C / Inert atmosphere

3: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: oxalyl dichloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

5: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

With pyridine; sodium azide; oxalyl dichloride; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.06.004

Reference yield:

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 1448816-36-1
1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid / acetic acid / 1 h / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / Inert atmosphere

2.2: 4 h / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere

4.1: tin(II) chloride dihdyrate / ethyl acetate / 20 h / 60 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

6.1: oxalyl dichloride; pyridine / dichloromethane / 4 h / 20 °C / Inert atmosphere

7.1: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

With pyridine; sodium azide; oxalyl dichloride; tin(II) chloride dihdyrate; nitric acid; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide; 2.1: |Dakin Phenol Oxidation / 2.2: |Dakin Phenol Oxidation;
DOI:10.1016/j.bmcl.2013.06.004