ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

Base Information

Chemical Name:ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate
CAS No.:638215-13-1
Molecular Formula:C₂₄H₃₄BrNO₅Si
Molecular Weight:524.527
Hs Code.:

Synonyms:ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

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Chemical Property of ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

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Technology Process of ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

There total 2 articles about ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403612-14-6
(4-hydroxy-2-methylphenoxy)acetic acid ethyl ester

: 638215-11-9
1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethanol

: 638215-13-1
ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 24.5h;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 638215-13-1
ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.33 h / -78 °C / Cooling with acetone-dry ice

1.2: 0.25 h / -78 °C

1.3: 1.25 h / -78 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24.5 h / 0 - 20 °C

With n-butyllithium; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; hexanes; 2.1: Mitsunobu reaction;

Reference yield:

: 638215-13-1
ethyl ({4-[(1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethyl)oxy]-2-methylphenyl}oxy)acetate

: 638216-64-5
({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 21 h / 45 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.03 h / 0 °C

3.2: 18 h / 0 - 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Suzuki Coupling;