({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

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Chemical Name:({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid
CAS No.:638216-64-5
Molecular Formula:C₂₆H₂₆F₃NO₅
Molecular Weight:489.491
Hs Code.:

Synonyms:({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

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Chemical Property of ({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

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Technology Process of ({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

There total 6 articles about ({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 638215-15-3
ethyl ({4-[(2-hydroxy-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]-2-methylphenyl}oxy)acetate

: 107-08-4
1-iodo-propane

: 638216-64-5
({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: ethyl ({4-[(2-hydroxy-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]-2-methylphenyl}oxy)acetate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.0333333h;

1-iodo-propane; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

Reference yield:

: 403612-14-6
(4-hydroxy-2-methylphenoxy)acetic acid ethyl ester

: 638216-64-5
({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24.5 h / 0 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 21 h / 45 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.03 h / 0 °C

4.2: 18 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Mitsunobu reaction / 2.1: Suzuki Coupling;

Reference yield:

: 638215-11-9
1-(6-bromo-2-pyridinyl)-2-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}ethanol

: 638216-64-5
({2-methyl-4-[(2-(propyloxy)-1-{6-[4-(trifluoromethyl)phenyl]-2-pyridinyl}ethyl)oxy]phenyl}oxy)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 24.5 h / 0 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 21 h / 45 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.03 h / 0 °C

4.2: 18 h / 0 - 20 °C

With di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; sodium carbonate; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; 1.1: Mitsunobu reaction / 2.1: Suzuki Coupling;