(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

Base Information

Chemical Name:(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione
CAS No.:1134584-06-7
Molecular Formula:C₁₈H₂₂N₂O₄
Molecular Weight:330.384
Hs Code.:

Synonyms:(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

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Chemical Property of (+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

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Technology Process of (+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

There total 1 articles about (+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 882994-24-3
(+)-(1S,5S)-6-allyl-8-(4-methoxybenzyl)-6,8-diazabicyclo-[3.2.2]nonane-2,7,9-trione

: 1134584-06-7
(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

Guidance literature:: With lithium borohydride; In tetrahydrofuran; at -78 ℃; for 3h; diastereoselective reaction;
DOI:10.1021/jm801522j

Reference yield: 96.0%

: 1134584-06-7
(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

: 124-63-0
methanesulfonyl chloride

: 1134635-48-5
(+)-(1S,2R,5S)-6-allyl-8-(4-methoxybenzyl)-7,9-dioxo-6,8-diazabicyclo[3.2.2]nonan-2-yl methanesulfonate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.bmc.2008.11.043

Reference yield: 94.0%

: 1134584-06-7
(+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

: 100-39-0
benzyl bromide

: 1134584-10-3
(+)-(1S,2R,5S)-6-allyl-2-benzyloxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

Guidance literature:: (+)-(1S,2R,5S)-6-allyl-2-hydroxy-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; paraffin oil; for 0.333333h; Inert atmosphere; Cooling with ice;

benzyl bromide; In tetrahydrofuran; paraffin oil; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm801522j