Technology Process of 3-(naphthalen-2-yl)-5,5-diphenyl-4,5-dihydroisoxazole
There total 5 articles about 3-(naphthalen-2-yl)-5,5-diphenyl-4,5-dihydroisoxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate;
In
N,N-dimethyl-formamide;
at 140 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ol4014969
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / dichloromethane / 0 - 20 °C
2: tetrahydrofuran / 5 h / 0 - 75 °C / Sealed tube
3: hydroxylamine hydrochloride; pyridine / ethanol / 60 °C / Inert atmosphere
4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate / N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere
With
pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydroxylamine hydrochloride; potassium carbonate;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol4014969
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tetrahydrofuran / 5 h / 0 - 75 °C / Sealed tube
2: hydroxylamine hydrochloride; pyridine / ethanol / 60 °C / Inert atmosphere
3: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium carbonate / N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere
With
pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydroxylamine hydrochloride; potassium carbonate;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol4014969
