(3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Base Information

• Chemical Name: (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate
• CAS No.: 1352630-62-6
• Molecular Formula: C₂₂H₂₆N₂O₃
• Molecular Weight: 366.46
• Mol file: 1352630-62-6.mol

Synonyms:(3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Chemical Property of (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

There total 3 articles about (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-methyl-2-(pyrrolidin-1-yl)phenyl)-2-oxoacetate (1352630-68-2) + 4-methoxy-aniline (104-94-9) → (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate (1352630-62-6) + (3aS,5R)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate + ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Guidance literature:

With C₄₂H₂₈O₉P₂; In toluene; at 115 ℃; for 72h; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetlet.2011.10.062

Reference yield:

2-bromo-5-methylaniline (53078-85-6) → (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate (1352630-62-6) + (3aS,5R)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate + ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / toluene / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

2.2: 0.33 h / -78 °C

3.1: C₄₂H₂₈O₉P₂ / toluene / 72 h / 115 °C

With n-butyllithium; C₄₂H₂₈O₉P₂; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/j.tetlet.2011.10.062

Reference yield:

1-(2-bromo-5-methylphenyl)pyrrolidine (1352630-66-0) → (3aR,5S)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate (1352630-62-6) + (3aS,5R)-ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate + ethyl 4-(4-methoxyphenyl)-8-methyl-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinazoline-5-carboxylate

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C

1.2: 0.33 h / -78 °C

2.1: C₄₂H₂₈O₉P₂ / toluene / 72 h / 115 °C

With n-butyllithium; C₄₂H₂₈O₉P₂; In tetrahydrofuran; hexane; toluene;

DOI:10.1016/j.tetlet.2011.10.062

upstream raw materials:

1-(2-bromo-5-methylphenyl)pyrrolidine

ethyl 2-(4-methyl-2-(pyrrolidin-1-yl)phenyl)-2-oxoacetate

4-methoxy-aniline

2-bromo-5-methylaniline