(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

Base Information

Chemical Name:(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid
CAS No.:635292-24-9
Molecular Formula:C₂₀H₂₇NO₄
Molecular Weight:345.439
Hs Code.:

Synonyms:(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

Chemical Property:

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Technology Process of (+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

There total 5 articles about (+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 635292-23-8
(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

: 635292-24-9
(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 70 ℃;
DOI:10.1021/jm030226n

Reference yield:

: 152857-42-6
1-(2-hydroxymethyl)propylallylamine

: 635292-24-9
(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

4.1: 91 percent / aq. NaOH / ethanol / 70 °C

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In ethanol; dichloromethane; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/jm030226n

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 635292-24-9
(+/-)-(Z)-4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

4.1: 91 percent / aq. NaOH / ethanol / 70 °C

With sodium hydroxide; oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In ethanol; dichloromethane; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/jm030226n