(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

Base Information

Chemical Name:(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate
CAS No.:635292-23-8
Molecular Formula:C₂₂H₃₁NO₄
Molecular Weight:373.492
Hs Code.:

Synonyms:(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

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Chemical Property of (+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

Chemical Property:

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Technology Process of (+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

There total 4 articles about (+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31641-78-8
ethyl 2-diethoxyphosphoryl-2-phenylacetate

: 635292-22-7
allyl-(1-formyl-propyl)-carbamic acid tert-butyl ester

: 635292-23-8
(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

Guidance literature:: ethyl 2-diethoxyphosphoryl-2-phenylacetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In acetonitrile; at 20 ℃; for 0.5h;

allyl-(1-formyl-propyl)-carbamic acid tert-butyl ester; In acetonitrile; at 20 ℃;
DOI:10.1021/jm030226n

Reference yield:

: 152857-42-6
1-(2-hydroxymethyl)propylallylamine

: 635292-23-8
(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

With oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In dichloromethane; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/jm030226n

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 635292-23-8
(+/-)-(Z)-ethyl 4-(N-allyl-N-tert-bytoxycarbonylamino)-2-phenyl-2-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 13 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 3.5 h / -78 - 20 °C

3.1: LiCl; DBU / acetonitrile / 0.5 h / 20 °C

3.2: 24 mg / acetonitrile / 20 °C

With oxalyl dichloride; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; In dichloromethane; acetonitrile; 2.1: Swern oxidation;
DOI:10.1021/jm030226n