2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate

Base Information

• Chemical Name: 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate
• CAS No.: 532986-87-1
• Molecular Formula: C₁₈H₂₈NO₇P
• Molecular Weight: 401.397

Synonyms:2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate

Chemical Property of 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate

Chemical Property:

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Technology Process of 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate

There total 12 articles about 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

bis(2-cyanoethyl) 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl phosphate (532986-86-0) → 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate (532986-87-1)

Guidance literature:

bis(2-cyanoethyl) 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl phosphate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 3h; Heating;

With hydrogenchloride;

DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

methyl amino(3-hydroxyphenyl)acetate (130697-96-0) → 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate (532986-87-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2.1: K₂CO₃ / acetone / 8 h / Heating

3.1: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4.1: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5.1: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6.1: 100 percent / pyridine / 1 h / 0 °C

7.1: 93 percent / Et₃N; Pd(OAc)2; DPPP / methanol; dimethylsulfoxide / 2 h / 20 - 70 °C

8.1: 93 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

9.1: tetrazole / acetonitrile / 2 h / 20 °C

10.1: m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

11.1: DBU / tetrahydrofuran / 3 h / Heating

11.2: 38 percent / 1M HCl

With 1H-imidazole; 1H-tetrazole; palladium diacetate; lithium borohydride; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

n-octanoic acid chloride (111-64-8) → 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl dihydrogen phosphate (532986-87-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2.1: K₂CO₃ / acetone / 8 h / Heating

3.1: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4.1: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5.1: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6.1: 100 percent / pyridine / 1 h / 0 °C

7.1: 93 percent / Et₃N; Pd(OAc)2; DPPP / methanol; dimethylsulfoxide / 2 h / 20 - 70 °C

8.1: 93 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C

9.1: tetrazole / acetonitrile / 2 h / 20 °C

10.1: m-CPBA / CH₂Cl₂ / 0.5 h / 0 °C

11.1: DBU / tetrahydrofuran / 3 h / Heating

11.2: 38 percent / 1M HCl

With 1H-imidazole; 1H-tetrazole; palladium diacetate; lithium borohydride; 1,3-bis-(diphenylphosphino)propane; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.1016/S0968-0896(02)00381-4

upstream raw materials:

bis(2-cyanoethyl) 2-(3-methoxycarbonylphenyl)-2-(octanoylamino)ethyl phosphate

methyl amino(3-hydroxyphenyl)acetate

n-octanoic acid chloride

methyl (3-hydroxyphenyl)(octanoylamino)acetate

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