2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

Base Information

Chemical Name:2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt
CAS No.:1365990-78-8
Molecular Formula:C₁₈H₁₂ClN₇S*ClH
Molecular Weight:430.32
Hs Code.:

Synonyms:2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

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Chemical Property of 2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

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Technology Process of 2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

There total 14 articles about 2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1365992-82-0
C₂₈H₂₈ClN₇O₄S

: 1365990-78-8
2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 5h; Inert atmosphere;

Reference yield:

: 17282-04-1
2-chloro-3-fluoropyridine

: 1365990-78-8
2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 4.67 h / -70 °C

1.2: 2 h / -70 - 20 °C

2.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

3.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

4.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

4.2: 1.5 h / Reflux

5.1: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; caesium carbonate; thiourea; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; n-heptane; ethylbenzene; isopropyl alcohol;

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 1365990-78-8
2-[4-(6-amino-2-methylpyrimidin-4-ylamino)-thiazolo[5,4-c]pyridin-2-yl]-3-chlorobenzonitrile hydrochloride salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1.5 h / Inert atmosphere; Reflux

2.1: thionyl chloride / 18 h / 100 °C / Inert atmosphere

3.1: thiourea; pyridine / isopropyl alcohol / 3 h / Inert atmosphere; Reflux

3.2: 1.5 h / Reflux

4.1: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C

5.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

6.1: hydrogenchloride / 1,4-dioxane / 5 h / 50 °C / Inert atmosphere

With pyridine; hydrogenchloride; thionyl chloride; caesium carbonate; thiourea; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; isopropyl alcohol;