rifamycin S-O₂₁,O₂₃ acetonide

Base Information

Chemical Name:rifamycin S-O₂₁,O₂₃ acetonide
CAS No.:51757-14-3
Molecular Formula:C₄₀H₄₉NO₁₂
Molecular Weight:735.829
Hs Code.:

rifamycin S-O<sub>21</sub>,O<sub>23</sub> acetonide

Synonyms:rifamycin S-O₂₁,O₂₃ acetonide

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Chemical Property of rifamycin S-O₂₁,O₂₃ acetonide

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Technology Process of rifamycin S-O₂₁,O₂₃ acetonide

There total 1 articles about rifamycin S-O₂₁,O₂₃ acetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62623-68-1,76188-88-0,81203-58-9,101978-28-3,13553-79-2
rifamycin S

: 67-64-1
acetone

: 17555-51-0,86851-41-4,96789-07-0
Desacetyl-rifamycin S

: 51757-15-4
O²¹,O²³-isopropylidene-O²⁵-deacetyl-O¹,O⁴-didehydro-rifamycin

: 51757-14-3
O²¹,O²³-isopropylidene-O¹,O⁴-didehydro-rifamycin

Guidance literature:: rifamycin S; acetone; With dimethoxypropane; sulfuric acid; sodium carbonate; at 20 ℃; for 0.833333h;

With sodium hydroxide; In methanol; at 20 ℃; for 18h;

With citric acid; pH=4;

Reference yield: 95.0%

: 51757-14-3
rifamycin S-O₂₁,O₂₃ acetonide

: 13553-79-2,62623-68-1,76188-88-0,81203-58-9,101978-28-3
(+/-)-rifamycin S

Guidance literature:: With perchloric acid; In tetrahydrofuran; water; at 23 ℃; for 4h;
DOI:10.1016/S0040-4039(00)71481-X

Reference yield:

: 51757-14-3
rifamycin S-O₂₁,O₂₃ acetonide

: 77075-68-4
C₄₇H₅₅NO₁₄

Guidance literature:: Multi-step reaction with 6 steps

1: 80 percent / sodium hydroxide / 8 h / 0 °C

2: sodium ascorbate / 1,2-dimethoxy-ethane; H₂O / 23 °C

3: lithium hydroxide / 1,2-dimethoxy-ethane; H₂O / 32 h / 23 °C

4: aq. potassium ferricyanide / ethyl acetate

5: 2.) sodium hydroxide / 1.) pyridine, methylene chloride, ethylacetate, 23 deg C, 48 h 2.) water, THF, 23 deg C, 15 min

6: 97 percent

With lithium hydroxide; sodium hydroxide; sodium L-ascorbate; potassium hexacyanoferrate(III); In 1,2-dimethoxyethane; water; ethyl acetate;
DOI:10.1016/S0040-4039(00)71481-X