N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Base Information

Chemical Name:N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide
CAS No.:460048-72-0
Molecular Formula:C₃₇H₄₇N₅O₆
Molecular Weight:657.81
Hs Code.:

<i>N</i>-benzyl-<i>N</i>'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Synonyms:N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Suppliers and Price of N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

There total 8 articles about N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-46-9
benzylamine

: 460048-72-0
N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 84.22 percent / Et₃N / CHCl₃ / 12 h / 60 °C

2: 73.9 percent / DCC / CHCl₃ / 2 h / 20 °C

3: 63 percent / H₂; HCOOH / 10 percent Pd/C / methanol / 6 h / 20 °C / 3040 Torr

4: 27.4 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; 4: Ugi reaction;
DOI:10.1055/s-2002-31948

Reference yield:

: 64984-60-7
4-oxo-4-[(phenylmethyl)amino]butanoic acid

: 460048-72-0
N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 73.9 percent / DCC / CHCl₃ / 2 h / 20 °C

2: 63 percent / H₂; HCOOH / 10 percent Pd/C / methanol / 6 h / 20 °C / 3040 Torr

3: 27.4 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With formic acid; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; 3: Ugi reaction;
DOI:10.1055/s-2002-31948

Reference yield:

: 32331-52-5
N-benzyl glyoxylic amide

: 460048-72-0
N-benzyl-N'-({benzyl-[1-(2-benzylcarbamoyl-2-hydroxy-1-methyl-ethylcarbamoyl)-3-methyl-butyl]-carbamoyl}-methyl)-succinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

2.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

2.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

3.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

4.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

5.1: 27.4 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; dichloromethane; 5.1: Ugi reaction;
DOI:10.1055/s-2002-31948