64984-60-7

Basic information

• Product Name: 4-(BENZYLAMINO)-4-OXOBUTANOIC ACID
• Synonyms: 4-(BENZYLAMINO)-4-OXOBUTANOIC ACID;3-(BENZYLCARBAMOYL)PROPANOIC ACID;AKOS A1230-1957;AKOS BBB/327;BUTTPARK 163\40-83;OTAVA-BB 7110950149
• CAS NO: 64984-60-7
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.22582
• Mol File: 64984-60-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 483.3 °C at 760 mmHg
• Flash Point: 246.1 °C
• Appearance: /
• Density: 1.202 g/cm³
• Vapor Pressure: 3.75E-10mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 4-(BENZYLAMINO)-4-OXOBUTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BENZYLAMINO)-4-OXOBUTANOIC ACID(64984-60-7)
• EPA Substance Registry System: 4-(BENZYLAMINO)-4-OXOBUTANOIC ACID(64984-60-7)

Safety Data

• Hazardous Substances Data: 64984-60-7(Hazardous Substances Data)

Usage

General Description

4-(Benzylamino)-4-oxobutanoic acid is a chemical compound with the molecular formula C11H13NO3. It is a derivative of glutamic acid and is commonly used as a synthetic intermediate in the production of pharmaceuticals and other organic compounds. This chemical is a white solid with a molecular weight of 203.225 g/mol. It has various applications in the pharmaceutical industry, including as a building block in the synthesis of drugs and as a research tool in biochemical studies. 4-(Benzylamino)-4-oxobutanoic acid is also known by other names such as Benzyl (4-aminobutanoyl)pentanedioate and Benzyl (4-aminobutyryl)malonate.

InChI:InChI=1/C11H13NO3/c13-10(6-7-11(14)15)12-8-9-4-2-1-3-5-9/h1-5H,6-8H2,(H,12,13)(H,14,15)

Upstream product

• 100-44-7 benzyl chloride 
• 2142-06-5 1-(phenylmethyl)-2,5-pyrrolidinedione 
• 108-30-5 succinic acid anhydride 
• 100-46-9 benzylamine 
• 110-15-6 succinic acid 

Downstream Products

• 59578-63-1 4-(benzylamino)-1-butanol 
• 19340-88-6 N-benzyl-4-hydroxybutanamide 
• 1119393-47-3 1-benzyl-5-(1H-indol-3-yl)pyrrolidin-2-one 
• 1285559-99-0 1-benzyl-5-(2-methyl-1H-indol-3-yl)pyrrolidin-2-one 
• 1119393-48-4 1-benzyl-5-(2-p-tolyl-1H-indol-3-yl)pyrrolidin-2-one 
• 1285560-10-2 1-benzyl-5-(3-methyl-1H-indol-2-yl)pyrrolidin-2-one 
• 1285560-13-5 1-benzyl-5-[3-(4-methyl-phenyl)indol-2-yl]pyrrolidin-2-one 
• 41194-02-9 1-benzyl-5-hydroxypyrrolidin-2-one 
• 23496-31-3 1,3-dihydro-5-methyl-1-(phenylmethyl)-2H-pyrrol-2-one 
• 22568-12-3 1-benzyl-5-methylene-pyrrolidin-2-one 
• 5291-77-0 1-benzyl-2-pyrrolidone 
• 127419-78-7 1,5-bis(phenylmethyl)-2-pyrrolidinone 
• 927898-77-9 1,2-dibenzyl-2-hydroxypyrrolidin-5-one 
• 1621317-95-0 N¹-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N⁴-(phenylmethyl)succinamide 

Relevant articles and documents

Radical-mediated dehydrative preparation of cyclic imides using (NH4)2S2O8-DMSO: Application to the synthesis of vernakalant

Ammonium persulfate-dimethyl sulfoxide (APS-DMSO) has been developed as an efficient and new dehydrating reagent for a convenient one-pot process for the synthesis of miscellaneous cyclic imides in high yields starting from readily available primary amines and cyclic anhydrides. A plausible radical mechanism involving DMSO has been proposed. The application of this facile one-pot imide forming process has been demonstrated for a practical synthesis of vernakalant.

High affinity ligands and potent antagonists for the α1D- adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives

A new series of high affinity ligands and antagonists for the α1D-adrenergic receptor (AR) has been discovered. New molecules present a [1]benzothieno[3,2-d]pyrimidin-2,4(1H,3H)-dione or a [1]benzothieno[3,2-d]pyrimidin-4(3H)-one scaffold and bear a 2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl moiety in the 3-position and various amide substituents in the 8-position. In binding assays at the three human cloned α1A-, α1B-, and α1D-AR subtypes, they showed high affinity values, particularly for the α1D-AR subtype. Compound 22 (RX18), N1-methyl-N 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3, 4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-N1-(phenylmethyl) pentanediamide, was the most interesting in the series displaying very high affinity (pKi = 10.25) and potent antagonism (pKb = 9.15) when tested in a functional assay at the α1D-AR.

Solvent-mediated one-pot synthesis of cyclic N-Substituted imides

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