2-((2-Methoxyphenoxy)methyl)thiazolidine

Base Information

• Chemical Name: 2-((2-Methoxyphenoxy)methyl)thiazolidine
• CAS No.: 103181-68-6
• Molecular Formula: C₁₁H₁₅NO₂S
• Molecular Weight: 225.312
• Hs Code.: 2934999090
• European Community (EC) Number: 600-405-8,700-191-7
• DSSTox Substance ID: DTXSID10908225
• ChEMBL ID: CHEMBL341633
• Mol file: 103181-68-6.mol

Synonyms:2-((2-Methoxyphenoxy)methyl)thiazolidine;103181-68-6;2-[(2-methoxyphenoxy)methyl]-1,3-thiazolidine;Thiazolidine, 2-((2-methoxyphenoxy)methyl)-;2-((2-Methoxyphenoxy)methyl)-1,3-thiazolidine;Oprea1_227805;2-(2-METHOXYPHENOXY)-METHYL-1,3-THIAZOLIDINE;CHEMBL341633;SCHEMBL1920173;DTXSID10908225;RVDKSQDMEIWCNB-UHFFFAOYSA-N;2-(o-methoxyphenoxymethyl)thiazolidine;AKOS022175095;2-(o-methoxyphenoxy)methyl-thiazolidine;AC-25629;2-(2-methoxyphenoxy)-2-methylthiazolidine;LS-151432;FT-0707574

Chemical Property of 2-((2-Methoxyphenoxy)methyl)thiazolidine

Chemical Property:

• Vapor Pressure: 2.36E-05mmHg at 25°C
• Refractive Index: 1.549
• Boiling Point: 359.6 °C at 760 mmHg
• Flash Point: 171.3 °C
• PSA: 55.79000
• Density: 1.139 g/cm³
• LogP: 2.06530
• Storage Temp.: 2-8°C
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 225.08234989
• Heavy Atom Count: 15
• Complexity: 191

Purity/Quality:

97% ^*data from raw suppliers

2-((2-Methoxyphenoxy)methyl)thiazolidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCC2NCCS2

Technology Process of 2-((2-Methoxyphenoxy)methyl)thiazolidine

There total 4 articles about 2-((2-Methoxyphenoxy)methyl)thiazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.53%

2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane (1160183-64-1) + 2-mercaptoethylamine hydrochloride (156-57-0) → 2-(2-methoxy-phenoxymethyl)-1,3-thiazolidine (103181-68-6,119562-05-9,119562-07-1)

Guidance literature:

With hydrogenchloride; In water; isopropyl alcohol; at 79 - 80 ℃; for 8h; Product distribution / selectivity;

Reference yield: 76.0%

2-(2-methoxyphenoxy)acetaldehyde diethyl acetal (161364-38-1) + 2-mercaptoethylamine hydrochloride (156-57-0) → 2-(2-methoxy-phenoxymethyl)-1,3-thiazolidine (103181-68-6,119562-05-9,119562-07-1)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 4h; Heating;

DOI:10.1021/jm00003a014

Reference yield:

2(2-methoxyphenoxy)ethanale (18167-91-4) + 2-mercaptoethylamine hydrochloride (156-57-0) → 2-(2-methoxy-phenoxymethyl)-1,3-thiazolidine (103181-68-6,119562-05-9,119562-07-1)

Guidance literature:

With potassium hydrogencarbonate; In water; for 4h; Ambient temperature;

DOI:10.1021/jm00003a014

upstream raw materials:

2(2-methoxyphenoxy)ethanale

2-mercaptoethylamine hydrochloride

2-(2-methoxyphenoxy)acetaldehyde diethyl acetal

2-[(2-methoxyphenoxy)methyl]-1,3-dioxolane

Downstream raw materials:

2-<(2-methoxyphenoxy)methyl>-3-<2-(methylthio)acetyl>-1,3-thiazolidine

(E)-3-(3,4-Dihydroxy-phenyl)-1-[2-(2-methoxy-phenoxymethyl)-thiazolidin-3-yl]-propenone

2-<(2-methoxyphenoxy)methyl>-3-acetyl-1,3-thiazolidine

2-<(2-methoxyphenoxy)methyl>-3-(2-chloroacetyl)-1,3-thiazolidine